Inductive influence of testosterone upon central sexual maturation in the rat.

نویسندگان

  • W N Adams Smith
  • M T Peng
چکیده

The influence of the testis and of testosterone upon the development of the male genitalia has been extensively investigated and a number of reviews of this work have been published (Jost, 1960; Burns, 1961). However, Witschi (1957) has stressed the need to distinguish between adult sex hormones, such as testosterone, and the secretions of the immature gonad. The formation of corpora lutea in the ovaries transplanted to adult male rats which had been castrated at birth, and the absence of corpus luteum formation in ovaries transplanted to male hosts bearing transplanted testes in the neck from birth, was reported by Pfeiffer in 1936. Similar observations have been reported by Yazaki (1960) and Harris (1964). A single injection of testosterone propionate has been found to lead to permanent sterility and a loss of corpus luteum formation in the ovaries of mice (Barraclough & Leathern, 1954) and rats (Barraclough, 1961). The present investigation was undertaken to see whether testosterone propionate would suppress corpus luteum formation in ovarian tissue transplanted to male rats castrated on the day of birth.

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عنوان ژورنال:
  • Journal of embryology and experimental morphology

دوره 17 1  شماره 

صفحات  -

تاریخ انتشار 1967